The Ulytau Region was established on June 8, 2022. It is located in the central part of Kazakhstan. The regional center is the city of Zhezkazgan. The total area of the region is 188.9 thousand square kilometers. The population is 220,300 people (according to the census data as of July 1, 2025).

On March 16, 2022, the President of the Republic of Kazakhstan, Kassym-Jomart Tokayev, announced the creation of the Ulytau Region during his Address to the Nation at a joint session of the Parliament, by separating part of the territory from the Karaganda Region.